High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying

Ozdemir-Kumral Z. N., KOYUNCUOĞLU T., ARABACI TAMER S., KAYA Ö. T., Koroglu A. K., YÜKSEL M., ...Daha Fazla

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, cilt.27, sa.2, ss.265-278, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5056/jnm20206
  • Dergi Adı: JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.265-278
  • Anahtar Kelimeler: Cholecystokinin, Gastric emptying, Nesfatin-1, Nitric oxide synthase type I, Vasoactive intestinal peptide, DISTENSION-SENSITIVE NEURONS, GLUCAGON-LIKE PEPTIDE-1, CHOLECYSTOKININ, INFLAMMATION, SECRETION, RECEPTOR, MOTILITY, SATIETY, OBESITY, RAT
  • Marmara Üniversitesi Adresli: Evet

Özet

Neither HFD nor NES-1 changed methylcellulose emptying, but NES-1 delayed saline emptying in cannulated ND-rats. Inhibitory effect of NES-1 on gastric emptying in ND-rats was reversed by all antagonists, and abolished in HFD-rats. In HFD-rats, carbachol-induced contractility was enhanced in gastric, but inhibited in ileal strips. HFD increased body weight, while serum triglycerides, alanine transaminase, aspartate aminotransferase, glucose, and levels of malondialdehyde, glutathione, myeloperoxidase activity, and luminolchemiluminescence in hepatic, ileal, and adipose tissues were similar in ND- and HFD-rats, but only lucigenin-chemiluminescence was