Severe creatine kinase increase during quetiapine and mirtazapine treatment

Rabus S., Izzettin F., Rabus M., Bilici M.

PSYCHOPHARMACOLOGY, vol.185, no.2, pp.263-264, 2006 (SCI-Expanded) identifier

  • Publication Type: Article / Letter
  • Volume: 185 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1007/s00213-005-0273-3
  • Journal Name: PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.263-264
  • Marmara University Affiliated: Yes

Abstract

In the literature, there have been several publications reporting creatine kinase (CK) increases associated with the use of atypical antipsychotic drugs. In this letter, I would like to present a case in which there was a massive increase in serum CK levels together with relatively modest increases in serum CK myoglobin-band (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels during quetiapine and mirtazapine treatment, without the presence of neuroleptic malignant syndrome (NMS).