Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone-Targeted Antiresorptives

Oktay S., Chukkapalli S. S. , Rivera-Kweh M. F. , Velsko I. M. , Holliday L. S. , Kesavalu L.

JOURNAL OF PERIODONTOLOGY, cilt.86, sa.1, ss.137-145, 2015 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1902/jop.2014.140302
  • Sayfa Sayıları: ss.137-145


Background: Periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. Oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and the success of antiresorptive treatments will rely on how effectively they can ameliorate periodontal disease-induced oxidative stress during oral infection.