Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone-Targeted Antiresorptives


Oktay S., Chukkapalli S. S., Rivera-Kweh M. F., Velsko I. M., Holliday L. S., Kesavalu L.

JOURNAL OF PERIODONTOLOGY, cilt.86, sa.1, ss.137-145, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1902/jop.2014.140302
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.137-145
  • Anahtar Kelimeler: Alendronate, bacteria, periodontal, enoxacin, lipid peroxidation, oxidative stress, periodontal diseases, VACUOLAR H+-ATPASE, GINGIVAL CREVICULAR FLUID, LIPID-PEROXIDATION LEVELS, TOTAL OXIDANT STATUS, DNA-DAMAGE, ANTIOXIDANT, DISEASE, ENOXACIN, RESORPTION, OSTEOCLASTOGENESIS
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background: Periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. Oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and the success of antiresorptive treatments will rely on how effectively they can ameliorate periodontal disease-induced oxidative stress during oral infection.