Esophageal smooth muscle reactivity is impaired in chronic reflux esophagitis by both receptor- and nonreceptor-mediated mechanisms


Tugtepe H., Tugay M., Bozkurt S. , Yildiz F., Utkan T., Yegen B. , ...More

JOURNAL OF PEDIATRIC SURGERY, vol.42, no.4, pp.641-646, 2007 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jpedsurg.2006.12.048
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.641-646

Abstract

Aim: Esophagitis is associated with an impaired esophageal peristalsis. A few studies have been aimed at understanding the pathophysiology of abnormal peristaltic activity. The mechanism of impaired esophageal smooth muscle reactivity in the chronic gastroesophageal reflux (GER) model is investigated in vitro for the first time.