Akademik Veri Yönetim Sistemi
Eurasian Journal of Medical Investigation, cilt.5, sa.2, ss.256-262, 2021 (Hakemli Dergi)
Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive ofsurvival for different types of cancer. Aim of present study is to investigate the association between PNI and survivaloutcomes in patients with soft tissue sarcoma (STS) operated with curative intent. Methods: We retrospectively collected data of 86 patients with localized STS. Preoperative PNI was calculated with thefollowing formula:10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm3 ). Patients were classified into 2groups based on median PNI value. Results: Median age was 52.5 (18-86) years. There were 49 male and 37 female patients. Most common histology wasliposarcoma (26.7%). Our cohort mainly included stage 3 (69.8%) and grade 3 (66.3%) tumors. Radiotherapy and chemotherapy were applied to 69.8% and 48.8% of patients, respectively. Median value of PNI was 48.2 (25.5-68.0). Medianfollow-up duration was 25 months (3-120). Median overall survival (OS) was 84.6 months (95% CI, 72.0-97.3). MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (<48.2), being 99.6 months(95%CI, 83.6-115.6) and 64.5 months(95% CI, 50.3-78.7), respectively(p=0.02). Multivariate analysis determined PNI as anindependent prognostic indicator for OS [HR: 2.96, (95% CI 1.11–7.87), p=0.02] along with age. Conclusion: Our findings suggest that PNI predicts OS independently in patients with STS. Therefore, PNI is a valuableprognostic tool in preoperative setting.