Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals

Eminzade S., Uraz F., Izzettin F. V.

NUTRITION & METABOLISM, vol.5, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2008
  • Doi Number: 10.1186/1743-7075-5-18
  • Journal Name: NUTRITION & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Marmara University Affiliated: Yes

Abstract

Background: The first line anti-tuberculosis drugs isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA) continues to be the effective drugs in the treatment of tuberculosis, however, the use of these drugs is associated with toxic reactions in tissues, particularly in the liver, leading to hepatitis. Silymarin, a standard plant extract with strong antioxidant activity obtained from S. marianum, is known to be an effective agent for liver protection and liver regeneration. The aim of this study was to investigate the protective actions of silymarin against hepatotoxicity caused by different combinations of anti-tuberculosis drugs.