Endocrine disrupting chemicals and bone.

Turan S.

Best practice & research. Clinical endocrinology & metabolism, cilt.35, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.beem.2021.101495
  • Dergi Adı: Best practice & research. Clinical endocrinology & metabolism
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: endocrine disrupting chemicals, bone, perfluoroalkyl substances, phthalate esters, dioxins, bisphenols, URINARY PHTHALATE METABOLITES, N-BUTYL PHTHALATE, HUMAN BREAST-MILK, MINERAL DENSITY, OSTEOCLAST DIFFERENTIATION, PERFLUOROALKYL SUBSTANCES, BISPHENOL-A, PPAR-GAMMA, DI(2-ETHYLHEXYL) PHTHALATE, PERFLUOROOCTANE SULFONATE
  • Marmara Üniversitesi Adresli: Evet

Özet

Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. EDCs exert their hormonal effects through several mechanisms; modulating hormone receptors or changing metabolism of different hormones. EDCs also influence multiple signalling pathways while effecting the hormonal systems and possess complex dose eresponse curves. EDCs can exert deleterious effects on bone tissue through changing bone modelling and remodelling via altering bone paracrine hormone synthesis, the release of systemic hormones, cytokines, chemokines and growth factors, and effecting stem cell fate, as well as bone marrow mesenchymal stem cell differentiation. Evidence is accumulating of the bone disrupting effect of different groups of EDCs, such as; the perfluoroalkyl substances, the phthalate esters, the bisphenol A, the organotin compounds, the alkylphenols and the dioxin and dioxin-like compounds. This review highlights the recent discoveries of the effects of commonly found environmental chemicals on bone from basic molecular findings to clinical implications. (C) 2021 Elsevier Ltd. All rights reserved.