Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

Kucukguzel, ŞÜKRİYE; Rollas, S

doi:10.1016/s0014-827x(02)01253-3

Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

Atıf İçin Kopyala

Kucukguzel Ş. G. , Rollas S.

FARMACO, cilt.57, sa.7, ss.583-587, 2002 (SCI İndekslerine Giren Dergi)

Cilt numarası: 57 Konu: 7
Basım Tarihi: 2002
Doi Numarası: 10.1016/s0014-827x(02)01253-3
Dergi Adı: FARMACO
Sayfa Sayıları: ss.583-587

Özet

Novel coupling products 7a-d and 4-arylhydrazono-2 pyrazoline-5-ones 8a-e were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium. Compound 7b was found to be the most potent derivatives of the 7a-d series by an MIC value of 6.25 mug/ml. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.