Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

Kucukguzel Ş. G., Rollas S.

FARMACO, cilt.57, sa.7, ss.583-587, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0014-827x(02)01253-3
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.583-587
  • Anahtar Kelimeler: coupling products, 4-arylhydrazono-2-pyrazoline-5-one, 1,2,4-triazole, hydrazide-hydrazones, DERIVATIVES, ACID
  • Marmara Üniversitesi Adresli: Evet

Özet

Novel coupling products 7a-d and 4-arylhydrazono-2 pyrazoline-5-ones 8a-e were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium. Compound 7b was found to be the most potent derivatives of the 7a-d series by an MIC value of 6.25 mug/ml. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.