Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

Kucukguzel Ş. G. , Rollas S.

FARMACO, vol.57, no.7, pp.583-587, 2002 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1016/s0014-827x(02)01253-3
  • Title of Journal : FARMACO
  • Page Numbers: pp.583-587

Abstract

Novel coupling products 7a-d and 4-arylhydrazono-2 pyrazoline-5-ones 8a-e were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium. Compound 7b was found to be the most potent derivatives of the 7a-d series by an MIC value of 6.25 mug/ml. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.