Is the presence of AA amyloidosis associated with impaired coronary flow reserve?

Bulut M., Keles N., Caliskan Z., Kostek O., Aksu F., Ozdil K., ...Daha Fazla

ATHEROSCLEROSIS, cilt.251, ss.389-395, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 251
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.atherosclerosis.2016.05.041
  • Dergi Adı: ATHEROSCLEROSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.389-395
  • Anahtar Kelimeler: AA amyloidosis, Coronary flow reserve, Atherosclerosis, TRANSESOPHAGEAL DOPPLER-ECHOCARDIOGRAPHY, NONINVASIVE ASSESSMENT, MICROVASCULAR DYSFUNCTION, BLOOD-FLOW, VELOCITY, ARTERY, INFLAMMATION, FEASIBILITY, COMMITTEE, DISEASE
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background and aims: Systemic amyloid A protein (AA) amyloidosis may occur as a complication of many chronic inflammatory disorders. Patients receiving inadequate anti-inflammatory and immunosuppressive therapies have an increased risk of developing systemic AA amyloidosis. Inflammation plays a role in all stages and the thrombotic complications of atherosclerosis. In the absence of epicardial coronary stenosis, coronary flow reserve (CFR) reflects coronary microvascular dysfunction. In the present study, we hypothesized that amyloid advanced subclinical inflammation in chronic inflammatory diseases (CID) patients may further affect coronary microcirculation.