Confirmation of an Association Between rs6822844 at the IL2-IL21 Region and Multiple Autoimmune Diseases

Maiti A. K., Kim-Howard X., Viswanathan P., Guillen L., Rojas-Villarraga A., Deshmukh H., ...More

ARTHRITIS AND RHEUMATISM, vol.62, no.2, pp.323-329, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1002/art.27222
  • Journal Name: ARTHRITIS AND RHEUMATISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.323-329
  • Marmara University Affiliated: Yes

Abstract

Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies.