D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model


Saridogan G. E., Aykac A., Cabadak H., Cerit C., Caliskan M., Gören M. Z.

BEHAVIOURAL BRAIN RESEARCH, cilt.293, ss.227-233, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 293
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.bbr.2015.07.050
  • Dergi Adı: BEHAVIOURAL BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.227-233
  • Marmara Üniversitesi Adresli: Evet

Özet

D-cycloserine (DCS), an FDA approved anti-tuberculosis drug has extensively been studied for its cognitive enhancer effects in psychiatric disorders. DCS may enhance the effects of fear extinction trainings in animals during exposure therapy and hence we investigated the effects of DCS on distinct behavioral parameters in a predator odor stress model and tested the optimal duration for repeated daily administrations of the agent.