Investigation of the Roles of Non-neuronal Acetylcholine in Chronic Myeloid Leukemic Cells and their Erythroid or Megakaryocytic Differentiated Lines

Aydın, BANU; Cabadak, HÜLYA; Gören, MEHMET

doi:10.2174/1871520618666180406123154

Investigation of the Roles of Non-neuronal Acetylcholine in Chronic Myeloid Leukemic Cells and their Erythroid or Megakaryocytic Differentiated Lines

Aydın B., Cabadak H., Gören M. Z.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, ss.1440-1447, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18
Basım Tarihi: 2018
Doi Numarası: 10.2174/1871520618666180406123154
Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1440-1447
Anahtar Kelimeler: Acetylcholinesterase, curare, vesamicole, hemicholinium 3, K562 cells, cholinergic, CHOLINERGIC SYSTEM, CLINICAL-ASPECTS, BIOLOGICAL-SYSTEMS, K562 CELLS, EXPRESSION, RELEASE, PROLIFERATION, LYMPHOCYTES, INDUCTION, APOPTOSIS
Marmara Üniversitesi Adresli: Evet

Özet

Background: Many studies suggested that Acetylcholine (ACh) might serve as an autocrine/paraerine growth factor in several types of tumors or tumor cell lines. High levels of Acetylcholinesterase (AChE) activity have been reported in primary brain tumors, ovarian, colon and lung tumors.