Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II).

Yilmaz Ö., Bayer B., Bekçi H., Uba A., Cumaoğlu A., Yelekci K., ...Daha Fazla

Medicinal chemistry (Shariqah (United Arab Emirates)), cilt.16, ss.735-749, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1573406415666190613162322
  • Dergi Adı: Medicinal chemistry (Shariqah (United Arab Emirates))
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.735-749
  • Anahtar Kelimeler: EGFR/PI3K/AKT pathway, LNCaP, flurbiprofen, thioether, methionine aminopeptidase, prostate cancer, METHIONINE AMINOPEPTIDASE-2 INHIBITOR, ANTI-HCV, PROGRESSION, FUMAGILLIN, TNP-470
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.