Ghrelin Alleviates Spinal Cord Injury in Rats Via Its Anti-inflammatory Effects

Ersahin M., Toklu H. Z., ERZİK C., AKAKIN D., TETİK Ş., ŞENER G., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.21, sa.4, ss.599-605, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5137/1019-5149.jtn.4736-11.0
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.599-605
  • Anahtar Kelimeler: Ghrelin, Spinal cord injury, Neuroprotective, Rat, NEURON-SPECIFIC ENOLASE, BRAIN-DAMAGE, CELL-DEATH, FUNCTIONAL RECOVERY, ENDOTHELIAL-CELLS, ACYLATED PEPTIDE, OXIDATIVE STRESS, NERVOUS-SYSTEM, ORGAN INJURY, MOUSE MODEL
  • Marmara Üniversitesi Adresli: Evet

Özet

AIM: Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Ghrelin, 28 amino-acid peptide, has been shown to modulate the release of proinflammatory cytokines and exert anti-inflammatory effects. The aim of the current study was to investigate the anti-inflammatory effects of ghrelin, in a rat model of SCI.