Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum


Toklu H. Z. , Yang Z., Oktay S. , Sakarya Y., Kirichenko N., Matheny M. K. , ...More

BEHAVIOURAL BRAIN RESEARCH, vol.340, pp.14-22, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 340
  • Publication Date: 2018
  • Doi Number: 10.1016/j.bbr.2017.04.025
  • Title of Journal : BEHAVIOURAL BRAIN RESEARCH
  • Page Numbers: pp.14-22
  • Keywords: Overpressure blast injury, Brain, Trauma, Lung, Edema, NGF, NF kappa B, GFAP, Iba1, NSE, TRAUMATIC BRAIN-INJURY, SUBARACHNOID HEMORRHAGE, BARRIER PERMEABILITY, BLOOD, MODEL, INFLAMMATION, DAMAGE, EXPRESSION, BIOMARKERS, SEVERITY

Abstract

Background & aim: Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI.