Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum

Toklu, Hale; Yang, Zhihui; Oktay, NİHAL; Sakarya, Yasemin; Kirichenko, Nataliya; Matheny, Michael; Muller-Delp, Judy; Strang, Kevin; Scarpace, Philip; Wang, Kevin; Tumer, Nihal

doi:10.1016/j.bbr.2017.04.025

Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum

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Toklu H. Z., Yang Z., Oktay S., Sakarya Y., Kirichenko N., Matheny M. K., ...More

BEHAVIOURAL BRAIN RESEARCH, vol.340, pp.14-22, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 340
Publication Date: 2018
Doi Number: 10.1016/j.bbr.2017.04.025
Journal Name: BEHAVIOURAL BRAIN RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.14-22
Keywords: Overpressure blast injury, Brain, Trauma, Lung, Edema, NGF, NF kappa B, GFAP, Iba1, NSE, TRAUMATIC BRAIN-INJURY, SUBARACHNOID HEMORRHAGE, BARRIER PERMEABILITY, BLOOD, MODEL, INFLAMMATION, DAMAGE, EXPRESSION, BIOMARKERS, SEVERITY
Marmara University Affiliated: Yes

Abstract

Background & aim: Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI.