Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole.


Altuncu E., Bilgen H. S. , Soysal A., ÖZEK E.

Case reports in pediatrics, cilt.2015, ss.402137, 2015 (Diğer Kurumların Hakemli Dergileri) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2015
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1155/2015/402137
  • Dergi Adı: Case reports in pediatrics
  • Sayfa Sayıları: ss.402137

Özet

Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients' blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.