Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation

Gungor B., Ekmekci A., ARMAN A., Ozcan K. S., Ucer E., Alper A. T., ...Daha Fazla

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, cilt.36, sa.10, ss.1220-1227, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1111/pace.12182
  • Dergi Adı: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1220-1227
  • Anahtar Kelimeler: lone atrial fibrillation, interleukin polymorphism, CRP, C-REACTIVE PROTEIN, OF-FUNCTION MUTATION, RECEPTOR ANTAGONIST, RISK, VARIANTS, RESTENOSIS, ANAKINRA, DISEASE, HEART, SUSCEPTIBILITY
  • Marmara Üniversitesi Adresli: Evet

Özet

BackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the inflammatory responses and genetic polymorphisms of IL-1 cluster genes are associated with increased risk for inflammatory diseases.