The incidence of systemic embolization with mechanical valves is 1% per year. Bacterial endocarditis, valvular heart disease, cardiomyopathies, atrial myxoma, cardiac arrhythmias, and acute coronary syndrome are the causes of coronary embolism. Although coronary embolism due to mechanical valve thrombosis is encountered rarely, it is an important and serious complication. There is no evidence-based effective treatment and management of coronary embolism. Here we report a case of myocardial infarction caused by coronary embolism due to mechanical mitral valve thrombosis.