Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats

Kabasakal, LEVENT; Sehirli, AO; Cetinel, ŞULE; Cikler, E; Gedik, N; Sener, GÖKSEL

doi:10.1016/j.lfs.2004.04.029

Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats

Kabasakal L., Sehirli A., Cetinel Ş., Cikler E., Gedik N., Sener G.

LIFE SCIENCES, cilt.75, sa.19, ss.2329-2340, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 75 Sayı: 19
Basım Tarihi: 2004
Doi Numarası: 10.1016/j.lfs.2004.04.029
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2329-2340
Anahtar Kelimeler: ischemia/reperfusion, mesna, lipid peroxidation, glutathione, myeloperoxidase, ISCHEMIA-REPERFUSION, TISSUE-INJURY, FREE-RADICALS, MYELOPEROXIDASE ACTIVITY, LIPID-PEROXIDATION, N-ACETYLCYSTEINE, KIDNEY, ANTIOXIDANT, DYSFUNCTION, MELATONIN
Marmara Üniversitesi Adresli: Evet

Özet

Reoxygenation of the ischemic tissue promotes the generation of various reactive oxygen metabolites (ROM) which are known to have deleterious effects on various cellular functions.