Thymoquinone Reduces Oxidative and Nitrosative Stress in Tongue-tissue of Rats Exposed to Total Cranial Irradiation

Taysi S., Baysal E., Demir E., Akan M., Binici H., ADLI M., ...More

WEST INDIAN MEDICAL JOURNAL, vol.65, no.3, pp.543-550, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.7727/wimj.2015.297
  • Journal Name: WEST INDIAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.543-550
  • Marmara University Affiliated: Yes

Abstract

Introduction: Head and neck cancer patients treated with radiotherapy suffer severe side-effects during and following their treatment. Efforts to decrease toxicity of irradiation to normal tissue, organs and cells have led to a search for cytoprotective agent. Investigations for effective and non-toxic compounds with radioprotective capability led to increasing interest in antioxidant such as thymoquinone (TQ).