Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

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Conti F., Oswaldo Lugo-Reyes S., Blancas Galicia L., He J., AKSU G., de Oliveira E. B., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.138, no.1, pp.241-251, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 138 Issue: 1
• Publication Date: 2016
• Doi Number: 10.1016/j.jaci.2015.11.041
• Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.241-251
• Keywords: Mycobacteria, BCG, chronic granulomatous disease, tuberculosis, primary immunodeficiency, CLINICAL-FEATURES, 1ST REPORT, 2 CHILDREN, TUBERCULOSIS, MUTATIONS, INFECTIONS, SUSCEPTIBILITY, VACCINATION, OXIDASE, REGION
• Marmara University Affiliated: Yes

Abstract

Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex. From the first year of life onward, most affected patients display multiple, severe, and recurrent infections caused by bacteria and fungi. Mycobacterial infections have also been reported in some patients.