PTPN22 gene polymorphism in Takayasu's arteritis

Sahin N., Aksu K., Kamali S., Bicakcigil M., Oezbalkan Z., Fresko I., ...Daha Fazla

Rheumatology, cilt.47, sa.5, ss.634-635, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1093/rheumatology/ken106
  • Dergi Adı: Rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.634-635
  • Anahtar Kelimeler: Takayasu's arteritis, single nucleotide polymorphism, PTPN22, SINGLE-NUCLEOTIDE POLYMORPHISM, LYMPHOID TYROSINE PHOSPHATASE, ASSOCIATION, CLASSIFICATION, ALLELE
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.