An efficient separation and method development for the quantifying of two basic impurities of Nicergoline by reversed-phase high performance liquid chromatography using ion-pairing counter ions


Yalcin G., Yuktas F. N.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.42, ss.434-440, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jpba.2006.04.032
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Sayfa Sayıları: ss.434-440

Özet

A quantification method was developed for the two basic impurities, one of which is also a metabolite, of Nicergoline (NIC), by using reversed-phase high performance liquid chromatography (RP-HPLC) and diode array detector (DAD). One of these compounds, 10-methoxy-6-methylergoline-8 beta-methanol-5-bromo-3-pyridinecarboxylate (1-DN) is the metabolite as well as the impurity whereas, the other 10-methoxy-1,6-dimethylergoline-8 beta-methanol-5-chloro-3-pyridinecarboxylate (5-CN) is only an impurity.