Effects of Different Concentrations of Injectable Collagenase Enzyme on Capsular Tissue Around Silicone Implants: A Preliminary Experimental Study for the Development of a New Treatment Strategy

Yesiloglu N., Temiz G., Sarici M., Yildiz K., Sirinoglu H., Guvercin E., ...Daha Fazla

AESTHETIC PLASTIC SURGERY, cilt.40, sa.1, ss.164-173, 2016 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00266-015-0600-y
  • Sayfa Sayıları: ss.164-173


In recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren's and Peyronie's diseases.