Akademik Veri Yönetim Sistemi
Journal of Reproductive Medicine, Gynaecology & Obstetrics, cilt.9, 2024 (Hakemli Dergi)
Infertility, a common condition characterized by a couple's inability to conceive after one year of unprotected intercourse. It explores the various factors contributing to infertility, such as genetic variations, lifestyle choices, and environmental factors, and their substantial influence on reproductive health. The text analyzes the constraints of traditional infertility treatments like hormonal therapies and Assisted Reproductive Technologies (ART), emphasizing the need for new therapeutic methods. The paper emphasizes the potential of regenerative medicine, specifically stem cell and exosome therapies, as promising alternatives that can target the fundamental cellular and molecular dysfunctions in infertility. The text delves into the regenerative potential of stem cell therapy for repairing damaged reproductive tissues and the function of exosome therapy in facilitating cellular communication and tissue repair. It highlights their capacity to provide individualized and minimally invasive treatment alternatives. The review also discusses the therapeutic possibilities of Mesenchymal Stem Cell-Derived Extracellular Vesicles (MSC-EVs) for treating female reproductive disorders like Polycystic Ovary Syndrome (PCOS), Premature Ovarian Insufficiency (POI), and Intrauterine Adhesion (IUA). It highlights their inherent therapeutic characteristics, decreased likelihood of causing immune responses, and improved biological durability. The text explores how MSC-EVs aid in functional interactions such as endometrium repair, fibrosis suppression, immunomodulation, and apoptosis inhibition in ovarian granulosa cells. The review supports incorporating regenerative therapies into clinical practice to enhance reproductive outcomes. It presents a fresh viewpoint on the changing field of infertility treatments and their ability to surpass the constraints of conventional methods, giving new hope to individuals and couples dealing with infertility issues.