TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in behçet's disease patients in two ethnic cohorts

Turunc G., Coskun D., Alibaz-Oner F. , Coit P., Duzgun N., ALPSOY E., ...More

Clinical and Experimental Rheumatology, vol.31, 2013 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31
  • Publication Date: 2013
  • Title of Journal : Clinical and Experimental Rheumatology
  • Keywords: Behcet's disease, TIRAP, genetic susceptibility, ASSOCIATION, MAL/TIRAP


Objective. The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations. Methods. Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays. Results. Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11). Conclusion. TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study. © Clinical and Experimental Rheumatology 2013.