Presence of lipoprotein lipase S447X stop codon affects the magnitude of interleukin 8 release after cardiac surgery with cardiopulmonary bypass

Ak, KORAY; Isbir, Selim; Tekeli, Atike; Ergen, Arzu; Atalan, Nazan; Dogan, Selami; Civelek, Ali; Arsan, SİNAN

doi:10.1016/j.jtcvs.2007.03.017

Presence of lipoprotein lipase S447X stop codon affects the magnitude of interleukin 8 release after cardiac surgery with cardiopulmonary bypass

Ak K., Isbir S., Tekeli A., Ergen A., Atalan N., Dogan S., ...Daha Fazla

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.134, sa.2, ss.477-483, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 134 Sayı: 2
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.jtcvs.2007.03.017
Dergi Adı: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.477-483
Marmara Üniversitesi Adresli: Evet

Özet

Objective: Current data suggest that individual genetic predisposition may influence the magnitude of cytokine response and the degree of organ dysfunction after cardiopulmonary bypass. Lipoprotein lipase S447X polymorphism has been shown to be protective against atherosclerosis. The aim of the study was to investigate the effect of lipoprotein lipase S447X polymorphism on cytokine release and early outcome after cardiopulmonary bypass.