Presence of lipoprotein lipase S447X stop codon affects the magnitude of interleukin 8 release after cardiac surgery with cardiopulmonary bypass


Ak K. , Isbir S., Tekeli A., Ergen A., Atalan N., Dogan S., ...Daha Fazla

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.134, ss.477-483, 2007 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 134 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jtcvs.2007.03.017
  • Dergi Adı: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
  • Sayfa Sayıları: ss.477-483

Özet

Objective: Current data suggest that individual genetic predisposition may influence the magnitude of cytokine response and the degree of organ dysfunction after cardiopulmonary bypass. Lipoprotein lipase S447X polymorphism has been shown to be protective against atherosclerosis. The aim of the study was to investigate the effect of lipoprotein lipase S447X polymorphism on cytokine release and early outcome after cardiopulmonary bypass.