Assessment of individual bioequivalence using sufficient bootstrap procedure

Beyaztas U.

PHARMACEUTICAL STATISTICS, cilt.18, sa.3, ss.388-398, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/pst.1930
  • Dergi Adı: PHARMACEUTICAL STATISTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.388-398
  • Marmara Üniversitesi Adresli: Hayır

Özet

This paper proposes a sufficient bootstrap method, which uses only the unique observations in the resamples, to assess the individual bioequivalence under 2 x 4 randomized crossover design. The finite sample performance of the proposed method is illustrated by extensive Monte Carlo simulations as well as a real-experimental data set, and the results are compared with those obtained by the traditional bootstrap technique. Our records reveal that the proposed method is a good competitor or even better than the classical percentile bootstrap confidence limits.