Production of microneedle patches coated with polyvinyl-alcohol/sucrose/gentamicin sulfate for skin treatment

Mutlu M. E., Akdag Z., Pilavci E., ULAĞ S., DAĞLILAR S., GÜNDÜZ O.

Materials Letters, cilt.378, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 378
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.matlet.2024.137557
  • Dergi Adı: Materials Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: 3D printing, Biomaterials, Digital light processing (DLP), Gentamicin sulfate, Microneedle, Polyvinyl alcohol (PVA), Sucrose
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, resin-based microneedle (MN) patches were fabricated using a digital light processing (DLP) printer. The needles were coated with gentamicin sulfate (GEN)-loaded with 13.3 % PVA/25 % sucrose solution by immersion. The SEM results showed that the coating was homogeneous and uniformly conical. Analysing the in vitro release profiles of GEN, it was found that it was ultimately released within 312 h. The compression test results demonstrated that GEN addition increased the compression strength to the value of 2.17 ± 0.01 N/mm2.