Role of testosterone to estradiol ratio in predicting the efficacy of recombinant human chorionic gonadotropin and testosterone treatment in male hypogonadism

Celik M., Ozcelik S., Bas S., Sariaydin M., Ozcelik M., GÖZÜ H.

ARCHIVES OF ENDOCRINOLOGY METABOLISM, cilt.65, sa.5, ss.617-624, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.20945/2359-3997000000399
  • Dergi Adı: ARCHIVES OF ENDOCRINOLOGY METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.617-624
  • Anahtar Kelimeler: Hypogonadism, testosterone to estradiol ratio, morning erection, ERECTILE DYSFUNCTION, HYPOGONADOTROPIC HYPOGONADISM, PENILE TUMESCENCE, MEN, DIAGNOSIS, THERAPY, HORMONE
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: We aimed to investigate the role of testosterone to estradiol ratio in predicting the effectiveness of human chorionic gonadotropin and testosterone treatments in male hypogonadism. Materials and methods:Thirty-six male patients with hypogonadotropic hypogonadism were included in the study. Seventeen (47.2%) patients received weekly recombinant human choriogonadotropin alpha (hCG) treatment (group-1) and 19 (52.8%) received testosterone replacement therapy (T treatment) every 21 days (group-2). Under these treatments, adequate frequency of morning erection (0_3/week), testosterone to estradiol ratio (T/E), and testicular volume changes were analyzed. Results: The mean age of the patients was 28.5 +/- 8.7 years. When the frequency of morning erection (0_3/week) was specified as adequate, the cut-off value for effective T/E ratio was found to be 12.0 (sensitivity 93.8%, specificity 90.0%). There was no significant difference between the treatment groups in terms of total testosterone levels, T/E ratio, or frequency of morning erections (0_3/week) (p 0.05). However, there was a statistically significant difference between the groups in terms of median left-right testicular volume in favor of group-1 (p < 0,05). Conclusion: In patients with hypogonadism who are under treatment, elevated estradiol-induced erectile dysfunction symptoms may persist even if serum testosterone levels are normal. Testosterone to estradiol ratio can be used as a predictive value in the effective treatment of hypogonadotropic hypogonadism with hCG and T. Arch Endocrinol Metab. 2021;65(5):617-24