Is Low Serum Klotho Level Associated with Alterations in Coronary Flow Reserve?

Keles N., ÇALIŞKAN M., Dogan B., Aksu F., Bulur S., Keles N. N., ...Daha Fazla

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, cilt.33, sa.6, ss.881-888, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/echo.13176
  • Dergi Adı: ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.881-888
  • Anahtar Kelimeler: coronary flow reserve, coronary artery disease, Klotho, TRANSESOPHAGEAL DOPPLER-ECHOCARDIOGRAPHY, ENDOTHELIAL DYSFUNCTION, NONINVASIVE ASSESSMENT, VELOCITY RESERVE, BLOOD-FLOW, ARTERY, DISEASE, FEASIBILITY, ADENOSINE, SEVERITY
  • Marmara Üniversitesi Adresli: Hayır

Özet

BackgroundThe Klotho gene, described as an aging suppressor gene, encodes a single-pass transmembrane protein. The extracellular part of Klotho is cleaved and released into the circulation where it may function as a vasculoprotective hormone. Coronary flow reserve (CFR) is accepted as a marker of coronary microvascular dysfunction when epicardial coronary stenosis is absent. There are no data regarding the relationship between serum Klotho levels and disorders in coronary microcirculation in healthy adults. We aimed to investigate the association between serum Klotho levels and alterations in coronary microcirculation in healthy adults using echocardiographic measurements of CFR.