Akademik Veri Yönetim Sistemi
MARMARA MEDICAL JOURNAL, cilt.38, sa.3, ss.190-197, 2025 (ESCI)
Purpose: To investigate the
radioprotective and prophylactic effects of Myrtus communis (MC) in
genitourinary tissues in an animal model.
Methods: Female rats (n=30)
were divided into four groups. The control group (C) (n=6) received only oral
saline (SF) for four days. Ionizing radiation (IR) groups were organized as
"IR group (IR)" (n=8) received oral SF for four days starting on the
day of administration; "MC treatment group (MC-tx)" (n=8) received
oral MC for four days beginning on the day of irradiation, and "MC
pretreatment group (MC-Ptx)" (n=8) received oral MC for a total of eight
days starting four days before irradiation. MC was administered by oral gavage.
Irradiation was performed as 10 Gy in a single fraction. On the fourth day of
irradiation, all rats were sacrificed, the tissues were examined
histopathologically, and Caspase-9 and Caspase-3 levels were examined using
western blotting to assess mitochondrial apoptosis.
Results: Radiation-induced
damage decreased in all treatment groups. Caspase-9 and Caspase-3 levels were
significantly reduced in the MC-Ptx and MC-tx compared to the IR in all tissues
(p<0.01).
Conclusion: Myrtus communis
significantly ameliorated ionizing radiation-induced damage to genitourinary
tissues by both prophylactic and therapeutic applications. Therefore, the
results of this study may contribute to the development of new strategies in
radioprotection.