Circulating endothelial cell number and markers of endothelial dysfunction in previously preeclamptic women

Tuzcu Z. B., AŞICIOĞLU E., SÜNBÜL M., ÖZBEN SADIÇ B., Arikan H., KOÇ M.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol.213, no.4, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 213 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1016/j.ajog.2015.06.043
  • Journal Name: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: circulating endothelial cells, endothelial dysfunction, preeclampsia, pregnancy, vascular endothelial growth factor receptor-1, VON-WILLEBRAND-FACTOR, CARDIOVASCULAR-DISEASE, RENAL-FUNCTION, HYPERTENSION, ASSOCIATION, INJURY, BLOOD, RISK
  • Marmara University Affiliated: Yes

Abstract

OBJECTIVE: Patients with preeclampsia (PE) have endothelial dysfunction and an increased future risk of cardiovascular (CV) mortality. The number of circulating endothelial cells (CECs) is markedly increased in conditions associated with a high degree of endothelial cell activation/injury including PE. We hypothesized that the number of CECs continues to be increased in women with a history of PE, reflecting ongoing endothelial cell activation/injury.