Akademik Veri Yönetim Sistemi
8TH INTERNATIONAL "BAŞKENT" CONGRESS ON MEDICINE, NURSING, AND HEALTH SCIENCES, Ankara, Türkiye, 4 - 06 Şubat 2023, ss.237, (Özet Bildiri)
Student Name: EDANUR ÇAKMAK
Name of Supervisor: PROF.DR. AHMET ARMAN
Objective: Multiple Sclerosis is defined as a complex disease thought to
be caused by genetic and non-genetic factors. In this study, it was aimed to
determine whether there is a relationship between MS disease and rs1946518,
rs1946519 and rs187238 polymorphisms of IL-18 in the Turkish population.
Material and methods: AS-PCR method was used for
rs187238 single nucleotide polymorphism, and RFLP method using restriction
cutting enzymes was used for rs1946518 and rs1946519 polymorphisms. Imaging of
PCR results was done by agarose gel electrophoresis. The obtained data were
evaluated statistically.
Results: The relationship between polymorphisms and MS was
investigated by chi-square test. Values with a P value less than 0.05 were
considered statistically significant. The p value was calculated as 0.001 for
the 137G>C polymorphism, the p value was less than
0.001 for the 607C>A polymorphism, and the p
value was calculated as 0.1 for the 656 G>T polymorphism. As a result, a
significant relationship was found for 137G>C, 607C>A polymorphisms. No
significant relationship was found for the 656 G>T polymorphism.
Conclusion: Investigating the relationship between MS disease and IL18 gene
polymorphism provides a better understanding of the pathogenesis and genetic
background of the disease, and contributes to target therapies that can be
developed in the future.
Keywords: Multiple Sclerosis, polymorphism, IL-18, genetics