CANADIAN JOURNAL OF SURGERY, cilt.54, sa.5, ss.333-338, 2011 (SCI-Expanded)
Background: Increased free radical production, decreased antioxidant capacity and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Vitamin E is a powerful antioxidant and a scavenger of hydroxyl radicals, and it has been shown to have anti-inflammatory activities in tissues. We investigated the effects of vitamin E on inflammatory activities using an acetic acid (AA)induced ulcerative colitis model in rats.