In vitro effect of amikacin, imipenem, cefodizime, IFN alpha-2a alone and combinations of antibiotics with IFN alpha-2a on polymorphonuclear leukocyte function in chronic hepatitis patients

Adalati R., Gurer Ü., Cevikbas A., Johansson C.

CHEMOTHERAPY, cilt.47, ss.261-265, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1159/000048532
  • Dergi Adı: CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-265
  • Marmara Üniversitesi Adresli: Evet

Özet

The in vitro effect of amikacin (8 mug/ml), imipenem (30 mug/ml), cefodizime (10 mug/ml), interferon alpha -2a (IFN alpha -2a) (10 IU/ml) and antibiotic combinations with IFNa-2a on polymorphonuclear leukocyte (PMN) functions (phagocytosis and intracellular killing of Candida albicans blastospores) was investigated in chronic hepatitis B patients. Phagocytosis and candidacidal activity was not affected after pretreatment of PMNs with amikacin and imipenem (p > 0.05). Phagocytic activity was enhanced after pretreatment of PMNs with cefodizime and IFN alpha -2a compared with that of control PMNs (p < 0.05), but candidacidal activity was not affected by the same drugs (p > 0.05). Phagocytic and intracellular activity of PMNs were not affected by combinations of IFN alpha -2a and antibiotics (p > 0.05). Copyright (C) 2001 S. Ka rger AG, Baser.