The in vitro effect of amikacin (8 mug/ml), imipenem (30 mug/ml), cefodizime (10 mug/ml), interferon alpha -2a (IFN alpha -2a) (10 IU/ml) and antibiotic combinations with IFNa-2a on polymorphonuclear leukocyte (PMN) functions (phagocytosis and intracellular killing of Candida albicans blastospores) was investigated in chronic hepatitis B patients. Phagocytosis and candidacidal activity was not affected after pretreatment of PMNs with amikacin and imipenem (p > 0.05). Phagocytic activity was enhanced after pretreatment of PMNs with cefodizime and IFN alpha -2a compared with that of control PMNs (p < 0.05), but candidacidal activity was not affected by the same drugs (p > 0.05). Phagocytic and intracellular activity of PMNs were not affected by combinations of IFN alpha -2a and antibiotics (p > 0.05). Copyright (C) 2001 S. Ka rger AG, Baser.