The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy


GÜLÇEBİ İDRİZ OĞLU M. , Kendirli T., Turgan Z. A. , Patsalos P. N. , ONAT F.

EPILEPSY RESEARCH, cilt.148, ss.17-22, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 148
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.eplepsyres.2018.09.015
  • Dergi Adı: EPILEPSY RESEARCH
  • Sayfa Sayıları: ss.17-22

Özet

Objective: Assessment of the relevance between serum drug concentration to its therapeutic response is a valid monitoring strategy for the clinical efficacy of antiepileptic drugs (AEDs). Levetiracetam (LEV) is a broad spectrum AED with a possible anti-inflammatory effect. We aimed to determine the relationship between LEV concentrations and its therapeutic response, and the effect of LEV on IL1-beta concentrations in patients with epilepsy.