Fractional Anisotropy Changes After Several Weeks of Daily Left High-Frequency Repetitive Transcranial Magnetic Stimulation of the Prefrontal Cortex to Treat Major Depression

Kozel F. A., Johnson K. A., Nahas Z., Nakonezny P. A., Morgan P. S., Anderson B. S., ...More

JOURNAL OF ECT, vol.27, no.1, pp.5-10, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1097/yct.0b013e3181e6317d
  • Journal Name: JOURNAL OF ECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.5-10
  • Keywords: diffusion tensor imaging, transcranial magnetic stimulation, depression, mixed linear model analysis of repeated measures, CEREBRAL-BLOOD-FLOW, FRONTAL WHITE-MATTER, DIFFUSION TENSOR MRI, LATE-LIFE DEPRESSION, NEUROPSYCHIATRIC APPLICATIONS, BRAIN, RTMS, IMAGES, TMS, METAANALYSIS
  • Marmara University Affiliated: No

Abstract

Objectives: As part of a sham controlled treatment trial using daily left repetitive transcranial magnetic stimulation (rTMS), brain changes associated with 4 to 6 weeks of treatment were examined using diffusion tensor imaging to noninvasively evaluate prefrontal white matter (WM) microstructure. A decrease in fractional anisotropy values of the left prefrontal WM could indicate damage to the region.