2-Thiobarbituric acid addition improves structural integrity and controlled drug delivery of biocompatible pectin hydrogels

Guner O. Z., Kocaaga B., Batirel S., Kurkcuoglu O., Guner F. S.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.70, no.10, pp.703-711, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2020.1760272
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Page Numbers: pp.703-711
  • Keywords: Biopolymers, drug delivery systems, hydrogels, molecular dynamics, simulations, IN-VITRO EVALUATION, THIOLATED POLYMERS, CROSS-LINKING, SYSTEMS
  • Marmara University Affiliated: Yes

Abstract

Thiolated polymers are commonly preferred for biomedical applications with their good permeation properties providing them higher bioavailability. However, the thiolation process is mostly time-consuming series of chemical reactions. This study describes a simple irreversible thiol group integration to the pectin hydrogels by noncovalent bonding. We used 2-thiobarbituric acid (TBA) for thiolation. We proved with full-atom molecular dynamics simulations and experimental methods that TBA desertion is negligible. Pectin hydrogels become more flexible and their disintegration is delayed from 4 h up to four days with TBA addition. Also, hydrogels can successfully deliver the model drug, theophylline, showing a controlled release profile.