2-Thiobarbituric acid addition improves structural integrity and controlled drug delivery of biocompatible pectin hydrogels
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.70, sa.10, ss.703-711, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 10
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/00914037.2020.1760272
- Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
- Sayfa Sayıları: ss.703-711
- Anahtar Kelimeler: Biopolymers, drug delivery systems, hydrogels, molecular dynamics, simulations, IN-VITRO EVALUATION, THIOLATED POLYMERS, CROSS-LINKING, SYSTEMS
- Marmara Üniversitesi Adresli: Evet
Özet
Thiolated polymers are commonly preferred for biomedical applications with their good permeation properties providing them higher bioavailability. However, the thiolation process is mostly time-consuming series of chemical reactions. This study describes a simple irreversible thiol group integration to the pectin hydrogels by noncovalent bonding. We used 2-thiobarbituric acid (TBA) for thiolation. We proved with full-atom molecular dynamics simulations and experimental methods that TBA desertion is negligible. Pectin hydrogels become more flexible and their disintegration is delayed from 4 h up to four days with TBA addition. Also, hydrogels can successfully deliver the model drug, theophylline, showing a controlled release profile.