Physiological Biodistribution of (68)Ga-DOTA-TATE in Normal Subjects.

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Özgüven S., Filizoğlu N., Kesim S., Öksüzoğlu K., Şen F., Öneş T., ...Daha Fazla

Molecular imaging and radionuclide therapy, cilt.30, sa.1, ss.39-46, 2021 (Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/mirt.galenos.2021.37268
  • Dergi Adı: Molecular imaging and radionuclide therapy
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.39-46
  • Anahtar Kelimeler: Ga-68-DOTA-TATE, neuroendocrine tumors, PET/CT, somatostatin receptors, normal subjects, SOMATOSTATIN RECEPTOR SUBTYPES, NEUROENDOCRINE TUMORS, HUMAN GUT, PET/CT, EXPRESSION, LOCALIZATION, SCINTIGRAPHY, MANAGEMENT, PEPTIDE, TUBULES
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: Somatostatin is an endocrine peptide hormone that regulates neurotransmission and cell proliferation by interacting with G protein coupled somatostatin receptors (SSTRs). SSTRs are specific molecular targets of several radiotracers for neuroendocrine tumor (NET) imaging. Gallium-68 (Ga-68)-DOTA-TATE is widely used for positron emission tomography/computed tomography (PET/CT) imaging of SSTRs and has shown a higher affinity for SSTR2, the most common SSTR subtype found in NETs. We aimed to analyze the distribution pattern of Ga-68-DOTA-TATE in normal subjects.