Cleft Palate Craniofacial Journal, 2026 (SCI-Expanded, Scopus)
Objective: To compare osteomeatal complex (OMC) anatomical variations and nasal cavity airway volume between individuals with cleft lip and palate (CLP) and healthy controls using cone beam computed tomography (CBCT). Design: Retrospective, cross-sectional study. Setting: Department of dentomaxillofacial radiology. Patients/Participants: CBCT images of 200 individuals were evaluated: 100 patients with CLP (mean age 13.64 ± 4.32 years) and 100 age- and sex-matched controls (mean age 13.67 ± 4.32 years). Patients with syndromes, maxillofacial trauma, prior orthognathic surgery, or inadequate image quality were excluded. Main Outcome Measures: Presence of OMC anatomical variations and nasal cavity airway volume. Results: Agger nasi cells were the most common anatomical variation and hypertrophic turbinates were the most frequent pathology in both groups. Haller cells (p = 0.006) and nasal septal pneumatization (p = 0.001) were more prevalent in controls. In contrast, paradoxical middle turbinate (p = 0.015), nasal septal deviation (p = 0.001), and mucosal thickening (p = 0.001) were more frequent in CLP. Total nasal cavity airway volume did not differ significantly between groups. Conclusions: Individuals with CLP exhibit distinct OMC anatomical patterns compared with controls; however, total nasal cavity volume is not significantly altered. These findings indicate that regional OMC alterations and overall nasal cavity volume represent related but distinct anatomical constructs.