Colchicine resistance: Associated factors and their effect on health-related quality of life in patients with familial Mediterranean fever

Gursoy D. E., Gezer H. H., ÖZ N., Ozer A., Kasman S. A., DURUÖZ M. T.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, vol.25, no.11, pp.1239-1245, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1111/1756-185x.14407
  • Journal Name: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.1239-1245
  • Keywords: colchicine, drug therapy, familial Mediterranean fever, quality of life, RECOMMENDATIONS, MANAGEMENT, CHILDREN, THERAPY
  • Marmara University Affiliated: Yes

Abstract

Aim To determine the factors associated with colchicine resistance and the effect of colchicine resistance on health-related quality of life (QoL) in patients with familial Mediterranean fever (FMF). Methods Demographic and clinical features, MEFV gene mutations, and Pras disease severity scores were recorded. QoL was assessed using the Short Form-36 (SF-36) and FMF-QoL scales. Colchicine resistance was defined as at least 1 attack per month for 6 months at the maximum tolerated dose of colchicine in fully compliant patients. Results The mean age of 118 patients (90 female, 28 male) with FMF was 38.4 +/- 12.5 years. The percentage of colchicine-resistant patients was 19.5%. In univariable analysis, smoking (odds ratio [OR] = 2.885; 95% confidence interval [CI] = 1.104-7.539; P = 0.031), attack duration (OR = 1.955; 95% CI = 1.137-3.360; P = 0.015), presence of arthritis (OR = 5.235; 95% CI = 1.508-18.179; P = 0.009), and disease severity score (OR = 1.790; 95% CI = 1.334-2.402; P < 0.001) were associated with colchicine resistance. The FMF-QoL and subscales of SF-36 except for role emotional and vitality, were different between colchicine-resistant and non-resistant patients (P < 0.05). Conclusion Smoking, attack duration, presence of arthritis, and disease severity were associated with colchicine resistance in fully compliant FMF patients. Colchicine-resistant patients had poorer health-related QoL.