A double-blind, crossover, randomized dose-comparison trial of granisetron for the prevention of acute and delayed nausea and emesis in children receiving moderately emetogenic carboplatin-based chemotherapy

Berrak, Su; Ozdemir, Nihal; Bakirci, Nadi; Turkkan, Emine; Canpolat, Cengiz; Beker, Bahar; Yoruk, Asim

doi:10.1007/s00520-007-0242-y

A double-blind, crossover, randomized dose-comparison trial of granisetron for the prevention of acute and delayed nausea and emesis in children receiving moderately emetogenic carboplatin-based chemotherapy

Atıf İçin Kopyala

Berrak S. G., Ozdemir N., Bakirci N., Turkkan E., Canpolat C., Beker B., ...Daha Fazla

SUPPORTIVE CARE IN CANCER, cilt.15, sa.10, ss.1163-1168, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 10
Basım Tarihi: 2007
Doi Numarası: 10.1007/s00520-007-0242-y
Dergi Adı: SUPPORTIVE CARE IN CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1163-1168
Anahtar Kelimeler: granisetron, antiemetic, efficacy, chemotherapy, dose comparison, RECEPTOR ANTAGONISTS, ANTIEMETIC THERAPY, PROPHYLAXIS, EFFICACY, CANCER, DEXAMETHASONE, SAFETY
Marmara Üniversitesi Adresli: Hayır

Özet

Background Granisetron is a safe and effective prophylaxis for nausea and vomiting associated with moderate to highly emetogenic chemotherapy. Few trials have been conducted to determine the optimal effective dose of granisetron in children with cancer. The objective of this report was to compare two doses of granisetron in patients with optic pathway tumors receiving moderately emetogenic doses of carboplatin.