Akademik Veri Yönetim Sistemi
Turkish Society of Physiological Sciences, 49th Turkish Physiology Congress, 6–9 November 2024, Izmir, Türkiye, Volume 241, Issue S733, OC-68, İzmir, Türkiye, 6 - 09 Kasım 2025, ss.58, (Özet Bildiri)
OC-68
Effects of Chemotherapy and Chronic Aerobic Exercise on
Cognitive Functions in Glioblastoma Model Rats
Aslı Nur Bahar1, Leman Arslan Arıtürk1, Ikbal Tan2, Nisanur Duman2
,
Nurhan Beyza Düzgün2, Sakine Beyza Üstün2, Zülal Sorkun2, Banu
Taktak Karaca3, Dila Şener Akçora4, Özgür Kasımay1
1Marmara University, School of Medicine, Department of
Physiology, İstanbul, Türkiye
2Marmara University, School of Medicine, 3rd Year Medical
Students, İstanbul, Türkiye
3Marmara University, School of Medicine, Department of
Immunology, İstanbul, Türkiye
4Marmara University, School of Medicine, Department of Histology
and Embryology, İstanbul, Türkiye
AIM: Glioblastoma (GBM) is a common, aggressive brain tumors in
adults. Treatments like temozolomide (TMZ) and the tumor can
reduce patients' quality of life. This study evaluates the effects of
moderate aerobic exercise on oxidative stress and cognitive
functions in glioblastoma-bearing rats, with and without
chemotherapy.
METHODS: Male Sprague Dawley rats (n=50) were divided into five
groups: sham-operated (S), glioblastoma (GBM), glioblastoma +
temozolomide (GBM+T), glioblastoma+exercise (GBM+E), and
glioblastoma+temozolomide+exercise (GBM+T+E). Exercise groups
did moderate-intensity exercise for 8 weeks. Five weeks later,
1x106 glioma cells were injected to create the tumor model.
Temozolomide (10 mg/kg) or saline was administered for five days.
Spatial memory was assessed with the Y-maze test; anxiety with
the hole board test; and depressive symptoms with sucrose
preference and Porsolt tests. Brain tissue weight index,
malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity,
glutathione (GSH) levels, and superoxide dismutase (SOD) activities
were measured. ANOVA and Student’s t-test were used.
RESULTS: Spatial memory assessed by the Y-maze test decreased
in the GBM group but improvement with exercise and TMZ
(p<0.05-0.01). In the hole board test, anxiety was lower in the GBM
group but higher in the exercise groups (p<0.05-0.001). The
sucrose preference index was higher in the TMZ and TMZ+exercise
groups compared to the GBM and control groups (p<0.05-0.01). In
the Porsolt test, immobility time increased in the GBM group and
was suppressed with TMZ (p<0.05). The brain weight index
decreased in the GBM group but increased in the exercise groups
(p<0.05-0.001). MDA levels and MPO activity increased in the GBM
group and decreased with exercise and/or TMZ (p<0.05-0.01). SOD
activity was higher in the exercise and/or TMZ groups compared to
the GBM group (p<0.05-0.01).
CONCLUSIONS: GBM formation increases anxiety-like behavior,
decreases spatial memory, reduces brain weight index, and
elevates oxidative stress. Moderate exercise improved these
parameters. This study was supported by the TÜBİTAK 2209
Project.
Keywords: Glioblastoma, temozolomide, exercise, cognitive
function