Research Information System
Turk Hijyen ve Deneysel Biyoloji Dergisi, vol.79, no.2, pp.255-266, 2022 (Scopus)
© 2022. Turk Hijyen ve Deneysel Biyoloji Dergisi. All Rights Reserved.Objective: Determination of glomerular filtration rate is essential for kidney functions in obesity. Creatinine and cystatin C are used to determine glomerular filtration rate. Cystatin-c increases with the increase of adipose tissue. The study investigates the use of cystatin C in calculating the glomerular filtration rate in obese individuals. Methods: One hundred thirteen obese women were used in the study. The height of the patients was measured barefoot on a flat surface. A whole-body analysis was performed by bioimpedance device (Tanita-BC418), and body weight, body mass index (BMI), fat percentage, fat mass, fat-free mass were detected. Biochemical data were evaluated retrospectively. CKD-EPI-GFR (Chronic Kidney Disease Epidemiology Collaboration equation glomerular filtration rate), GFRepi-cr (creatinine-GFR), GFR-epi-cysc (cystatin C-GFR) and GFR-epi-cr-cysc (combined-GFR) values were calculated from the measured cystatin-c and creatinine values. Results: We found that GFR-epi-cr decreased with age and BMI, increased with height, GFR-epi-cysc decreased with age, BMI, fat percentage, fat mass, increased significantly with height, GFR-epi-cr-cysc decreased with age, BMI, fat percentage, fat mass. GFR-epi-cr, GFR-epi-cysc, GFR-epi-cr-cysc decreased with HCRP (High-C-reactif protein). Creatinine increased with age and decreased with GFR-epi-cr, GFR-epi-cysc, GFR-epi-cr-cysc. Cystatin-c increased with age, body weight, BMI, fat percentage, fat mass, and decreased GFR-epi-cr, GFR-epi-cysc, GFR-epi-crcysc. Conclusion: Cystatin C can pass through kidney glomeruli easily and used in GFR calculation. We found that while cystatin-c increases with increased adipose tissue in obese individuals, GFR-epi–cysc ve GFRepi-cr-cysc decreased. As well, HCRP increased with the fat percentage and fat mass. These results are essential in terms of inflammation, which is evident with the increase in adipose tissue, affects kidney functions in obese individuals. Our study is essential in raising awareness about GFR calculation and parameters used in the follow-up of kidney functions in obese individuals.Our study shows that to use of cystatin Cmay give wrong results to calculate GFR and follow up of kidney functions in obese individuals.