Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

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Atıf İçin Kopyala

Bozaykut P., Şahin A., Karademir Yılmaz B., Ozer N.

MECHANISMS OF AGEING AND DEVELOPMENT, cilt.157, ss.17-29, 2016 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 157
• Basım Tarihi: 2016
• Doi Numarası: 10.1016/j.mad.2016.07.001
• Dergi Adı: MECHANISMS OF AGEING AND DEVELOPMENT
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.17-29
• Anahtar Kelimeler: Nonalcoholic steatohepatitis, Hypercholesterolemia, Endoplasmic reticulum stress, Unfolded protein response, MicroRNAs, UNFOLDED PROTEIN RESPONSE, FATTY LIVER-DISEASE, NF-KAPPA-B, PERK-DEPENDENT REGULATION, C/EBP HOMOLOGOUS PROTEIN, TNF-INDUCED APOPTOSIS, COENZYME-A REDUCTASE, ER STRESS, OXIDATIVE STRESS, LIPID-METABOLISM
• Marmara Üniversitesi Adresli: Evet

Özet

Nonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease. (C) 2016 Elsevier Ireland Ltd. All rights reserved.