miRNA Regulation in Dental Stem Cells: From Development to Terminal Differentiation

Güllüoğlu Ş.

in: Dental Stem Cells, Fikrettin Şahin,Ayşegül Doğan,Selami Demirci, Editor, Springer, London/Berlin , Zürich, pp.47-67, 2016

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2016
  • Publisher: Springer, London/Berlin 
  • City: Zürich
  • Page Numbers: pp.47-67
  • Editors: Fikrettin Şahin,Ayşegül Doğan,Selami Demirci, Editor


Dental Stem Cells (DSCs) are emerging adult stem cells (ASCs) as a good cell source for stem cell-based therapies and tissue engineering approaches. MicroRNAs (miRNAs) are approximately 20 nucleotide long small RNA molecules which can coordinate many genes and pathways. miRNAs effectively regulate stem cell types ranging from embryonic stem cells (ESCs) to mesenchymal stem cells (MSCs), and DSCs are no exception. Numerous studies in which miRNA profiling of DSCs from different sources of the mature and immature teeth including pulp, periodontal ligament, follicle and apical papilla tissues have been made in order to determine the role of specific miRNAs in various functions, which may be important for DSC biology. Moreover, the miRNA expression levels are being monitored both between different steps of differentiation and in cells that are differentiated in vitro. Such data will help to better retain stemness of cells, and manipulate the differentiation process into desired lineages. In this book chapter, we seek to compile data resulting from miRNA studies in DSCs.