The effects of SNAI1 rs6125849 gene polymorphism on metastasis and survival in colorectal cancer: Preliminary results from Turkish subjects

Cevik M., Namal E., Sener N. D., Koksal U. I., Deliorman G., Ciftci C., ...Daha Fazla

GENE REPORTS, cilt.24, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.genrep.2021.101279
  • Dergi Adı: GENE REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • Anahtar Kelimeler: SNAI1, rs6125849, Colorectal Cancer, Gene polymorphism, Metastasis, EPITHELIAL-MESENCHYMAL TRANSITION, E-CADHERIN EXPRESSION, TRANSCRIPTIONAL REPRESSOR SNAIL, TUMOR-GROWTH, BREAST-CARCINOMA, EMT, INVASION, PROGRESSION, ALLIANCE, DOMINANT
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Since metastasis is one of the leading causes of high mortality in colorectal cancer, uncovering the molecular mechanisms underlying metastatic process has become important to find new treatment approaches. With this perspective, in this study we investigated effects of epithelial-mesenchymal transition (EMT) inducer SNAI1 rs6125849 gene polymorphism on different features of colorectal cancer.