Dental Follicle Mesenchymal Stem Cells Enhance CD4+Foxp3+ Regulatory T Cells in the Lymphocytes of Amyotrophic Lateral Sclerosis Patients

Genc, Deniz; Zibandeh, Noushin; ULUÇ, KAYIHAN; KAHRAMAN KOYTAK, PINAR; Gokalp, Muazzez; Tanridag, TÜLİN; AKKOÇ, TUNÇ

doi:10.5152/clinexphealthsci.2017.346

Dental Follicle Mesenchymal Stem Cells Enhance CD4+Foxp3+ Regulatory T Cells in the Lymphocytes of Amyotrophic Lateral Sclerosis Patients

Genc D., Zibandeh N., ULUÇ K., KAHRAMAN KOYTAK P., Gokalp M., Tanridag T., ...Daha Fazla

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.7, sa.3, ss.85-90, 2017 (ESCI, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 3
Basım Tarihi: 2017
Doi Numarası: 10.5152/clinexphealthsci.2017.346
Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.85-90
Marmara Üniversitesi Adresli: Evet

Özet

Objective: Amyotrophic lateral sclerosis (ALS) is a disorder that causes the degeneration of motor neurons. Currently, riluzole is the only effective drug used to treat ALS; however, it has limited clinical benefits. Stem cell-based therapy has been studied as a potential novel treatment strategy for ALS and has shown to have an anti-inflammatory effects when treating this disease. In this study, we studied the immunosuppressive effect of dental follicle mesenchymal stem cells (DFSCs) on peripheral blood mononuclear cells (PBMCs) of ALS patients.