Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease


Creative Commons License

Ciftci C., Melil S., Cebi Y., Ersoz M., Cagatay P., Kilicgedik M., ...Daha Fazla

LIPIDS IN HEALTH AND DISEASE, cilt.7, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1186/1476-511x-7-5
  • Dergi Adı: LIPIDS IN HEALTH AND DISEASE

Özet

Background: Nitric oxide (NO) is an endothelium derived relaxing factor (EDRF) which has an important role for regulating the heart-vessel physiology. The objective of this study was to evaluate the effects of the eNOS T-786C polymorphism on lipid parameters and the development of acute coronary syndrome (ACS) and coronary heart disease (CHD) for the first time in a Turkish study group. We have analyzed the genotype frequencies of the T-786C polymorphism of the eNOS gene in 10 ACS patients (5 men, 5 women), 20 CHD patients (14 men, 6 women), and 31 controls (10 men, 21 women), who were angiographically proven to have normal coronaries.